Intended for healthcare professionals

The genetics of psoriasis

Psoriasis is a common, chronic, immune-mediated inflammatory skin disorder with a prevalence of 2% in Caucasians. The most common clinical presentation is chronic plaque psoriasis; however, other subtypes, such as guttate and flexural psoriasis, are frequently encountered. Most cases (75%) of chronic plaque psoriasis present before the age of 40 (early-onset or type 1 psoriasis); late-onset cases presenting after the age of 40 years are classified as type 2 psoriasis. Severe forms of the disease can be associated with increased mortality and morbidity.
Dermatology in practice 2010; 17(4): 4–6
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