Intended for healthcare professionals

Urea creams in skin conditions: composition and outcomes

David Voegeli
Urea was the first organic compound to be synthesised in a laboratory from inorganic materials, and urea preparations were used in the late 19th and early 20th century for the topical treatment of infections. Interest in urea as a topical agent to treat dry skin disorders developed over 50 years ago, following the discovery that urea played an important role in moisture regulation, and was a key constituent of natural moisturising factor.
Dermatology in practice 2012; 18(3): 13–16
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