Intended for healthcare professionals

The dermo-epidermal junction: an important structure in dermatology

The dermo-epidermal junction comprises a complex network of interacting macromolecules, arranged to provide mechanical stability and adhesion between the epidermis and the underlying dermis. Disorders affecting the proteins of this region, whether resulting from genetic structural mutations or from attack by autoantibodies, result in defective adhesion producing either skin fragility or blistering. An understanding of this area helps to clarify the classification and pathogenesis of these diseases.
Dermatology in practice 2000; 8(1): 6–8
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