Intended for healthcare professionals

Serum autoantibodies and connective tissue disorders

Understanding the results of serum autoantibody tests for the diagnosis of connective tissue disorders (CTDs) can present challenges. This article highlights the utility and limitations of some of the commonly available tests. Antinuclear antibodies (ANAs) were first reported in 1957 and extractable nuclear antigens (ENAs) in 1959. Despite decades of research, it is still not entirely clear why such antibodies arise, nor have the roles of their target antigens been fully elucidated.
Dermatology in practice 2008; 16(1): 14–18
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