Pyoderma gangrenosum – recognition and treatment
PG is an immunologically mediated acute destructive ulcerating condition of the skin. It is characterised by severe pain, rapid centrifugal extension of ulceration and also by its response to immunosuppressive or immunomodulant therapy. Its effects are devastating and, unless prompt therapy is initiated, enormous tissue destruction can occur quite rapidly. In more than half of patients with PG, there is an associated autoimmune or malignant disease.
Dermatology in practice 2003; 11(3): 27–30
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