National safety guidelines for oral methotrexate
Oral methotrexate is an antimitotic drug that reduces cell division within the body. High doses are prescribed as a cytotoxic agent for certain cancers. Low doses are used for severe psoriasis and some inflammatory skin diseases. It can produce serious side-effects, such as suppression of the immune system. According to the National Patient Safety Agency (NPSA), ‘Oral methotrexate is a safe and effective medication if taken at the right dose and with appropriate monitoring’.
Dermatology in practice 2005; 13(3): 26–27
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