A practical approach to using methotrexate
Methotrexate is an antimetabolite that was first introduced as an anticancer drug. Due to its anti-inflammatory properties, it is now used – in much lower doses – for the treatment of joint, bowel and skin conditions. In dermatology, low-dose methotrexate is most commonly used to treat psoriasis that has not responded to topical treatments or phototherapy. It is also useful as a steroid sparing agent in bullous pemphigoid, pemphigus, sarcoidosis, dermatomyositis and the vasculitides. Recently, it has been used in morphoea and in mycosis fungoides.
Dermatology in practice 2009; 17(3): 22–25
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