Intended for healthcare professionals
Case study

Yellow-orange papuloeruptive lesions with haematological malignancy

Eimear O’Brennan, Rajeev Shukla, Arti Bakshi and Richard AG Parslew

BSs(Hons) MBChB MRCP St5 Dermatology1 
MBBS FRCP Consultant Paediatric Histopathologist1 
MBBS FRCP Consultant Histopathologist2  
MBChB MRCP Consultant Dermatologist2

1 Alder Hey Children’s Hospital, Alder Hey Children’s NHS Foundation Trust
2 The Royal Liverpool and Broadgreen University Hospital Trust

Clinical presentation
A 16-year-old male was referred with a six-month history of asymptomatic yellow-orange coloured papules affecting the face. Past medical history included common acute lymphoblastic leukaemia (ALL) diagnosed one year previously. He is being treated as per ALL regime B and is currently on Cycle 7 of maintenance chemotherapy, which includes vincristine, methotrexate, prednisolone and mercaptopurine. He is doing very well on this treatment. His past medical history includes depression and systemic candidiasis. Family history includes hyperlipidaemia, but no xanthomas were reported.

Clinical examination (see Figure 1a–c) revealed multiple symmetric, well-demarcated, flat, slightly infiltrated yellow-orange papules on the forehead, eyelids, nose, perioral and preauricular area. No plaques or bruising were noted. Dermoscopic evaluation revealed a reticular pattern of yellow amorphous homogenous structures with overlying branched and linear vessels.

Dermatology in practice 2018; 24(3): 74–75
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